muscimol – Calm Mushroom

Amanita Muscaria Tincture vs. Extract: A Deep Dive into Potency, Purity & Safe Preparation

When exploring the world of Amanita Muscaria for its potential benefits, you’ll often encounter two primary forms: tinctures and extracts. While both aim to deliver the mushroom’s bioactive compounds, their preparation methods, potency, and intended therapeutic results differ significantly. Understanding these distinctions is crucial for choosing the right product for your needs.

Amanita Muscaria Tinctures: Traditional & Accessible

Tinctures represent one of the more traditional and accessible Amanita Muscaria preparation methods. Generally simpler and less costly to produce than extracts, tinctures are typically made using alcohol as a solvent. For instance, a fresh Amanita Muscaria tincture often utilizes a 1:1 mushroom-to-alcohol ratio. Historically, this type of Amanita Muscaria tincture has been recognized as an effective antinociceptive agent, particularly for localized relief from pain in the joints and spine. It’s important to note that tinctures made from fresh mushrooms are typically recommended for external use only.

Conversely, dried Amanita Muscaria tinctures involve a higher concentration of alcohol and a different dilution ratio, typically ranging from 1:6 to 1:10. This form of Amanita Muscaria preparation can sometimes be used both internally and externally, depending on the specific application and safety considerations. The relative simplicity of their creation makes tinctures a popular choice for home preparation, requiring minimal special equipment, allowing individuals to explore Amanita Muscaria uses in a DIY context.

The Limitations of Tinctures: Potency, Purity, and the Muscimol Challenge

Despite their accessibility, a significant drawback of many homemade or basic Amanita Muscaria tinctures is their inherently low concentration of active substances. Critically, the precise percentages of key bioactive compounds like muscimol and the neurotoxic ibotenic acid are often unknown and uncontrolled in these preparations. This lack of standardization makes achieving consistent Amanita Muscaria dosage and predictable results challenging.

A fundamental scientific consideration also arises from the choice of solvent. While alcohol is commonly used, it’s a relatively poor solvent for muscimol, the primary psychoactive compound in Amanita Muscaria. Muscimol extraction is far more efficient when using water, as muscimol exhibits much greater solubility in water than in alcohol. This crucial chemical property dictates the effectiveness of any Amanita Muscaria preparation method, whether a tincture or an extract.

Amanita Muscaria Extracts: Unlocking Higher Potency and Purity

This is where Amanita Muscaria extracts offer a distinct advantage. Designed to achieve a significantly higher concentration of active substances, extracts move beyond the limitations of simple tinctures. The extract preparation process is a sophisticated endeavor, employing various solvents and advanced extraction techniques along with specialized equipment and expert knowledge. The result is an Amanita Muscaria product with a concentration of bioactive compounds far exceeding what can be achieved with a basic tincture, making them a true high-potency extract.

Types of Extracts and the Power of Standardization

Amanita Muscaria extracts come in various forms, including liquid, soft (often resembling resin, like our Amanita Muscaria Water-Based Resin Extract), and dry powders. While all extracts aim for higher concentration, the gold standard in the industry is the standardized mushroom extract. Unlike basic extracts, standardized versions guarantee a precise, fixed amount (expressed as a percentage) of one or more key active ingredients in every batch. This commitment to potency and purity mirrors practices in the pharmaceutical industry, where consistent dosing is paramount.

The primary advantage of standardized Amanita Muscaria extracts lies in their ability to deliver a specific and consistent dose and potency across every single item within a product batch. This ensures predictable Amanita Muscaria benefits and allows for precise control over the applied therapeutic dose, a critical factor for safety and efficacy.

Calm Mushroom’s Innovation: A Standardized Water-Based Amanita Muscaria Extract

At Calm Mushroom, we’ve pioneered an innovative approach to Amanita Muscaria preparation by developing a proprietary technology for obtaining a standardized water-based extract. Our process deliberately avoids the use of ethanol and high temperatures, ensuring the delicate bioactive compounds, beneficial polysaccharides, and natural vitamins present in the mushroom are optimally preserved.

What truly sets our extract apart is its unwavering commitment to potency and purity. Through precise analysis conducted in a specialized laboratory utilizing efficient Gas Chromatography-Mass Spectrometry (GC-MS) methods, the exact amount of muscimol and other key substances is meticulously standardized. This rigorous quality control guarantees a consistent, reliable product every time.

Ensuring Safety: Complete Ibotenic Acid Decarboxylation

A cornerstone of our commitment to safe Amanita Muscaria products is our meticulous technology and quality control throughout both the raw material drying and extraction phases. This process completely eliminates ibotenic acid, a potentially neurotoxic compound, from our final product. Through a precise ibotenic acid decarboxylation process, we convert this substance into the desired muscimol, simultaneously allowing us to detect and eliminate any other potentially dangerous concentrations of substances. This ensures that you receive a premium, safe, and effective water-based mushroom extract.

Experience the Difference with Calm Mushroom Extracts

The distinction between an Amanita Muscaria tincture and a high-potency extract is clear: it lies in consistency, concentration, and ultimately, the therapeutic potential. While tinctures offer a simpler, DIY approach, our advanced Amanita Muscaria extraction technology delivers unparalleled potency and purity.

As a result, Calm Mushroom offers a truly innovative product on the market: a natural, standardized water-based extract of Amanita Muscaria. With its high concentration of beneficial bioactive compounds and meticulous ibotenic acid removal, it empowers you to control your therapeutic dose with confidence and precision. Choose Calm Mushroom for a superior and safe Amanita experience.

Ready to explore the benefits? Discover our premium Calm Mushroom Standardized Water-Based Extract today.

Looking for other high-quality Amanita Muscaria products? Explore our range:

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TGA Laboratory analysis for Calm Mushroom Resin Extract

Sample No63 concentrate

Visual description

Dense, easily deformable, non-sticky, specific odor, slightly oily

DSC– differential scanning calorimetry (change in heat flow with temperature)

This % defining analysis was previously used, but with increasing concentration the method is too sensitive, which is illustrated by many peaks at 140 ° C.

Therefore, TGA (thermogravimetric method) will hence be used, in which the change in mass of the material was determined. Compared to the previous method, the material was not damaged but converted to melted state by determining the melting point, but the TGA method is a material destruction method, thus the material gets damaged. Each substance has its own temperature at which the structure collapses or, more precisely, becomes not functional, making it possible to determine the mass fraction of each substance in the material from the total mass that was initially introduced.

TGA: After 1st derivative (1 / min) the amount of substances present in 5-7 components can be seen.

The question here is, have you used any additives, or is there a possibility of any substance entering the press? Given that the largest amount in the composition should be muscimol, the largest peak appears from 536.97 ° C to 695.08 ° C, and using the law of mass loss, we can calculate each component (see Table 1), but the device offers the possibility to determine immediately in this range how much weight is lost, which is the loss of muscimol, respectively (8.5%). The temperature of destruction is not mentioned anywhere in the scientific literature, so an actual hypothesis has been put forward here, to the exclusion of other variants. The TGA method has a limited ability to determine the destruction temperatures of the other components because there is no theoretical information that can overlap.

Muscimol

NAME:	Muscimol
CHEMICAL NAME:	5- (Aminomethyl) -3 (2H) -isoxazolone
ALTERNATE CHEMICAL NAMES:	5- (aminomethyl) -3-isoxazolol, 5-aminomethyl-3-hydroxyisaxazole
ALTERNATE CHEMICAL NAMES:	3-hydroxy-5-aminomethylisoxazole; agarin, pantherine
CHEMICAL FORMULA	C4H6N2O2
MELTING POINT	175 ° (crystals) (DSC)
DESTRUCTION TEMPERATURE	600 ° C (Information obtained by us)

Given the possible presence of ibotenic acid in the DSC data (see Figure 3), its assumption may be negligible if the correct acquisition conditions were observed.

Ibotenic acid

NAME:	Ibotenic Acid
CHEMICAL NAME:	alpha-Amino-2,3-dihydro-3-oxo-5-iso-xazoleacetic acid
ALTERNATE CHEMICAL NAMES:	alpha-amino-3-hydroxy-5-isoxazoleacetic acid
ALTERNATE CHEMICAL NAMES:	amino- (3-hydroxy-5-isoxazolyl) acetic acid
CHEMICAL FORMULA	C5H6N2O4
MOLECULAR WEIGHT	158.11
MELTING POINT	151-152 ° (anhydrous crystals)
MELTING POINT	144-146 ° (monohydrate crystals)

Muscatone

NAME:	Muscazone
CHEMICAL NAME:	alpha-Amino-2,3-dihydro-2-oxo-5-oxazoleacetic acid
ALTERNATE CHEMICAL NAMES:	alpha-amino-2-oxo-4-oxazoline-5-acetic acid
CHEMICAL FORMULA	C5H6N2O4
MOLECULAR WEIGHT	158.11

As such, there are many different other substances in mushrooms that qualify as nutrients: vitamins A; B1B2; C; D1, PP. Mushrooms also contain minerals: potassium, phosphorus, iron; trace elements: zinc, copper, magnesium, iodine. Mushrooms are also rich in extracts. Of course, in the case of fly agaric, it is worth mentioning the pigment that gives red color. This means that both valuable substances and muscimol are ingested at the same time when consuming such a product.

Conclusion: Muscimol content 8.5% in a specific sample No63 concentrate.

2/14/2022

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Unraveling Hangxiety: How Alcohol Impacts GABA & How Muscimol Can Help

Ever woken up after a night of drinking with not just a headache, but a pervasive sense of dread, anxiety, or even panic? This phenomenon, often dubbed ‘hangxiety’ or alcohol-induced anxiety, is a common and often distressing experience. But what exactly causes these intense feelings of post-drinking anxiety, and what can be done to alleviate them?

Person experiencing hangover anxiety, looking stressed after a night of drinking. — Understanding the aftermath of over-indulgence and how it affects your mental well-being.

The Science Behind Hangxiety: Alcohol and GABA

From a scientific perspective, the answer largely revolves around Gamma-aminobutyric acid (GABA), the brain’s primary inhibitory neurotransmitter. GABA plays a crucial role in regulating neuronal excitability, essentially calming the brain and promoting emotional balance. Scientists identify GABA as key to understanding alcohol’s negative effects on mental well-being, particularly feelings of stress reduction, fear, and panic.

GABA’s Role in Your Nervous System

Our bodies possess intricate systems that cooperate to defend against harmful substances. GABA, alongside the excitatory neurotransmitter glutamate, is a central element in this defense, facilitating communication throughout the brain and nervous system support. GABA’s main purpose is to regulate the nervous system, which governs vital functions like balance, movement, thoughts, and senses. An imbalance, whether underactive or hyperactive, can lead to neurotransmitters misinterpreting ordinary situations as dangerous, resulting in increased anxiety relief and stress.

Chemical structure of Gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. — The chemical structure of Gamma-aminobutyric acid (GABA).

How Alcohol Disrupts GABA and Brain Health

Initially, alcohol acts as a depressant, enhancing GABA’s effects and leading to feelings of relaxation and reduced inhibition. However, chronic or excessive alcohol consumption significantly hinders the natural production of GABA. This GABA imbalance means the brain tries to compensate by reducing GABA receptors, leading to less inhibitory control. When alcohol is removed, the brain is left in a state of hyperexcitability, manifesting as the heightened anxiety relief and agitation characteristic of hangxiety.

Scientific studies indicate that excessive alcohol consumption can cause both short-term and long-term symptoms by depleting GABA production. This profound effect on neurotransmitters can result in significant damage to both physical and mental health, impacting cognitive function, motor skills, and judgment.

Detailed illustration of the human nervous system, showing brain and nerve pathways. — The intricate network of the human nervous system.

A ‘GABA withdrawal’ is far from pleasant, often leading to intrusive thoughts, constant worries, and other challenging mental health symptoms. Furthermore, a decrease in brain GABA levels can exacerbate existing mental health issues and potentially contribute to substance use relapses, underscoring the critical need for effective nervous system support and solutions for alcohol withdrawal symptoms.

Muscimol: A Natural Approach to Restoring Balance

For those seeking natural anxiety relief and a way to rebalance neurotransmitters, muscimol presents a compelling option. Muscimol, a compound found in certain mushroom supplements, is a powerful GABA agonist. This means it mimics the action of GABA in the brain, binding to GABA receptors and effectively increasing GABA transmission. By doing so, muscimol can help decrease anxiety levels and support overall brain health, aiding the body’s natural recovery process after alcohol consumption.

Chemical structure of Muscimol, a powerful GABA agonist. — The chemical structure of Muscimol.

Beyond Anxiety: Additional Benefits of Muscimol

Scientific research further highlights muscimol’s broad therapeutic potential. It has been shown to significantly improve sleep-wake state changes during alcohol withdrawal, reducing the percentage of active wakefulness and increasing the percentage of restorative REM sleep. This can be vital for individuals struggling with disrupted sleep patterns often associated with alcohol cessation.

Moreover, muscimol offers a protective effect against ethanol toxicity in the liver, contributing to improved liver function – a significant benefit given alcohol’s well-documented impact on this vital organ. This makes muscimol a promising compound for comprehensive mental and physical well-being recovery.

Embrace Calm with Calm Mushroom Products

At Calm Mushroom, we understand the challenges of hangxiety and the importance of nervous system support. Our Calm Mushroom products contain muscimol as the main active ingredient. By incorporating these natural remedies for anxiety into your routine, you can support your body in successfully combating hangxiety and mitigating other harmful effects caused by alcohol usage, promoting better brain health and cognitive function.

Explore our range of muscimol-rich mushroom supplements designed for your well-being:

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Calm Mushroom Extract: Unveiling the Science of Standardized Amanita Muscaria for Purity & Potency

The Science Behind Calm Mushroom: Pure, Standardized Amanita Muscaria Extract

At Calm Mushroom, we believe in the power of nature, perfected by science. Our **Calm Mushroom Amanita Muscaria Standardized Water-Based Extract** is the culmination of extensive research and a commitment to unparalleled purity and potency. We’ve meticulously perfected our extract creation process to ensure a consistent, **standardized muscimol extract** that stands apart.

Through advanced extraction techniques, we skillfully free beneficial polysaccharides and key active substances from indigestible chitin, preserving them in our premium extract. Crucially, our low-temperature dehydration and extraction process, which never exceeds 40°C, safeguards the integrity and high quality of the final product, including vital polysaccharides and vitamins.

Achieving Unmatched Standardization & Purity

Producing a truly effective **Amanita Muscaria extract** requires more than just raw material. While it takes approximately 600 grams of fresh fly agaric caps to yield 10 grams of our concentrated resin extract (a 1:60 ratio from fresh mushroom to resin extract), the inherent variability in mushroom active substance content (due to collection location, dehydration, and storage) poses a significant challenge. This is precisely why standardization is paramount.

Our unique **water-based mushroom extract** technology focuses on ensuring a consistent, **standard content of active substances**, primarily muscimol. By meticulously isolating beneficial compounds from chitin – a main, biologically useless substance in the fungus body – and preserving sensitive polysaccharides and vitamins at low temperatures, we guarantee a superior and **pure Amanita Muscaria** product.

Third-Party Verification: 14.5% Muscimol, 0% Ibotenic Acid

The quality and safety of our **premium Amanita Muscaria extract** are not just claims; they are scientifically proven. Analysis conducted in the scientific laboratory of Latvian University, utilizing the precise Gas Chromatography Mass Spectrometry (GC-MS) method, definitively confirms the superiority of our extract.

The results speak for themselves: our **Amanita Muscaria extract** contains an impressive **14.5% muscimol** and, critically, 0% harmful neurotoxic ibotenic acid. This makes Calm Mushroom extract a truly **non-toxic Amanita extract**, ensuring it is 100% ibotenic acid free and a **safe Amanita Muscaria extract** you can trust.

Through numerous extraction experiments and dozens of meticulous laboratory analyses, we’ve built unwavering confidence in the quality and consistent muscimol content of our product.

Developed by Experts: Calm Mushroom Standardized Water-Based Extract

This commitment to excellence led to collaboration with a diverse team of **scientists, chemists, doctors, and pharmacists** from across Europe and Canada. Their collective expertise culminated in the creation of our advanced technology for the industrial production of a truly **standardized water extract of Amanita Muscaria** – the Calm Mushroom Standardized Water-Based Extract.

Our **Calm Mushroom Extract** is formulated with 10% Amanita Muscaria resin, expertly dissolved in a blend of vegetable glycerin and water. It is the power of muscimol, its primary active ingredient, that gives this product its wide range of therapeutic effects.

Experience the Muscimol Benefits: Relief for Mind and Body

The unique properties of our **science-backed Amanita Muscaria** offer versatile support for your well-being:

Targeted Pain Relief: When applied topically to the skin, it can effectively alleviate localized discomfort.
Anxiety Reduction: A few drops held under the tongue for 1-2 minutes can provide significant relief for everyday anxiety, making it an ideal choice for those seeking **Amanita Muscaria for anxiety**.
Hangxiety & Stress Relief: Experience rapid relief from ‘hangxiety’ within 3-5 minutes, calming post-indulgence unease.
Improved Sleep Quality: Our extract can significantly aid with insomnia, offering a natural path to better rest and earning its reputation as **Amanita Muscaria for sleep**.

Beyond being **ibotenic acid free**, Calm Mushroom Standardized Water-Based Extract is also completely **alcohol-free**, thanks to its pure water-based formulation. As a **natural plant-based supplement** with a guaranteed standard content of muscimol, it truly embodies our dedication to natural wellness backed by rigorous scientific standards.